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1. Blumenthal M, Busse WR, Goldberg A, et al. (eds). The Complete Commission E Monographs: Therapeutic Guide to Herbal Medicines. Boston , MA : Integrative Medicine Communications, 1998, 108.

2. Sliutz G, Speiser P, Schultz AM, et al. Agnus castus extracts inhibit prolactin secretion of rat pituitary cells. Horm Metab Res 1993;25:253¡V5.

3. Böhnert KJ. The use of Vitex agnus castus for hyperprolactinemia. Quart Rev Nat Med 1997;Spring:19¡V21.

4. Schellenberg R. Treatment for the premenstrual syndrome with agnus castus fruit extract: prospective, randomized, placebo controlled study. BMJ 2001;20:134¡V7.

5. Lauritzen C, Reuter HD, Repges R, et al. Treatment of premenstrual tension syndrome with Vitex agnus-castus. Controlled, double-blind study versus pyridoxine. Phytomed 1997;4:183¡V9.

6. Dittmar FW, Böhnert KJ, Peeters M, et al. Premenstrual syndrome: Treatment with a phytopharmaceutical. Therapiwoche Gynäkol 1992;5:60¡V8.

7. Loch EG, Selle H, Boblitz N. Treatment of premenstrual syndrome with a phytopharmaceutical formulation containing Vitex agnus castus. J Women Health Gender-Based Med 2000;9:315¡V20.

8. Halaska M, Beles P, Gorkow C, Sieder C. Treatment of cyclical mastalgia with a solution containing Vitex agnus extract: results of a placebo-controlled double-blind study. The Breast 1999;8:175¡V81.

9. Bone K. Vitex agnus-castus: Scientific studies and clinical applications. Eur J Herbal Med 1994;1:12¡V5.

10. Milewicz A, Gejdel E, Sworen H, et al. Vitex agnus castus extract for the treatment of menstrual irregularities due to latent hyperprolactinemia. Arzneim Forsch 1993;43:752¡V6 [in German].

11. Amann W. Improvement of acne vulgaris following therapy with Agnus castus (Agnolyt). Ther Ggw 1967;106:124¡V6 [in German].

12. Blumenthal M, Busse WR, Goldberg A, et al. (eds). The Complete Commission E Monographs: Therapeutic Guide to Herbal Medicines. Boston , MA : Integrative Medicine Communications, 1998, 108.

¸gµh»P¸g«e¯g­Ô¸s(PMS)ªº¦ÛµMÀøªkPMS...Help is on the way!

¥[®³¤j°ü¤k°·±d¤â¥U¡§Women¡¦s Health for Canadians,¡¨ by Prentice Hall Canada, 2001.

If you are a woman between 20 and 45 chances are you are all too familiar with premenstrual syndrome, or PMS. After all it affects over one-half of women in this age group.No, it is not ¡§all in your head.¡¨ The symptoms are real and can be quite distressing, affecting both your physical and emotional well-being. But don¡¦t dismay, help is on the way. There are a variety of natural or complementary approaches that can help you beat the PMS blues.The symptoms Feeling emotional, crying for no reason, irritability, bloating, these are just some of the symptoms associated with PMS. Over 100 different symptoms have been linked to PMS ranging from mild to severe.PMS symptoms may start anywhere from two weeks to a few days before menstruation and then slowly diminish once menstruation has started.

 The list below outlines some of the most common symptoms.

¡P Mood swings, anxiety, depression 

¡P Bloating

¡P Breast tenderness or enlargement

¡P Acne and skin eruptions

¡P Headache and backache

¡P Joint pain and swelling

¡P Increased appetite

¡P Food cravings (salt and sugar)

¡P Changes in sex drive

¡P Fatigue

¡P Insomnia

¡P Constipation or diarrhea

¡P Nausea and vomiting

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If you suspect that you are suffering with PMS, talk to your doctor or health-care provider because there are other health conditions that can have similar symptoms.Unfortunately there is no simple blood test or marker to confirm a diagnosis of PMS. It is the cyclic pattern of your symptoms that will guide your doctor in making a diagnosis. Keeping a diary for several months, noting your symptoms and the severity (scale of 1 to 10) can be very helpful in this process.Causes The symptoms of PMS are triggered by hormonal imbalance.Normal fluctuations in hormone levels before menstruation,along with dietary, lifestyle and environmental factors,can contribute to this imbalance. Here are some of the hormones and other factors that play a role:

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Aldosterone ¡V a hormone released by the adrenal gland.Stress can increase levels of aldosterone, causing water retention and bloating.

Estrogen ¡V Estrogen levels are high the week before menstruation, which can cause fluid retention, breast swelling and tenderness, nausea, and headache. Poor diet, stress, obesity and liver dysfunction can further increase estrogen levels and lead to a situation known as ¡§estrogen dominance.¡¨

Progesterone ¡V levels are low during menstruation,causing headaches, anxiety, nervousness, and irritability.

Serotonin ¡V a chemical messenger in the brain that regulates mood, emotions and satiety. Levels are low in women that suffer with PMS, causing depression,increased appetite, and cravings for sweets.

Nutritional deficiencies ¡V a lack of vitamins B, C, E,selenium, and magnesium can hinder the body¡¦s ability to break down estrogens and also lead to a deficiency of essential neurotransmitters, such as serotonin and dopamine.

Excess consumption of caffeine (cola, coffee, tea, and chocolate) can aggravate the emotional symptoms (anxiety, nervousness, insomnia and depression). Even one cup a day can be damaging!

A diet high in refined sugar and flour can cause mood swings and irritability. This type of diet often equates to a lack of nutritious fresh fruits,vegetables, whole-grains, and fibre.

Obesity ¡V carrying excess body fat can contribute to ¡§estrogen dominance¡¨ since body fat manufactures the female hormone estrone (an estrogen).

Treatment Options

I often see drugs such as antidepressants, tranquilizers and pain- killers prescribed for women struggling with PMS.While drugs may be necessary for women suffering with severe symptoms, these ¡§magic bullets¡¨ do have drawbacks:side effects, health risks, nutrient depletion and even addiction. I see more and more women today looking for natural, non-drug approaches to manage their health.Simple changes to your diet and lifestyle, along with the use of herbs and nutritional supplements can be very effective in managing PMS.

Dietary recommendations:

This is often the hardest step; making changes to your diet. Many of the foods we crave during PMS: chocolate,salty snack foods, and caffeine, can actually contribute to our symptoms. If these foods are part of your daily diet,make small and gradual changes to adopt a healthier diet.Focus on eating lots of fresh vegetables, fruit, whole grains, nuts, seeds, and fish products. An occasional treat is not a problem, but if these foods constitute your average daily diet then making some changes is essential.Not only will this diet help to lessen your PMS symptoms,it will also improve your overall health.

Lifestyle:Exercise and stress management are key components to health, and can significantly reduce many PMS symptoms.Exercise stimulates the release of endorphins, which are naturally occurring chemicals that help alleviate depression and pain. For this reason, these chemicals are commonly referred to as ¡§happy hormones.¡¨ Exercise comes in many forms, and offers great health rewards for a small investment in time. Walking, playing tennis,swimming,biking, and even doing housework with vigor count!

Exercise is also a great way to reduce stress ¡V and stress is a significant factor with PMS, along with many other health conditions. Stress causes the release of certain hormones, such as cortisol, adrenalin and aldosterone,which can aggrevate or even initiate PMS symptoms, such as bloating, headache, and depression. There is something that we can do about this because stress is our internal response to external stimuli (job, traffic, spouse). Learn what your stressors are, and find effective ways to minimize or avoid these forces. Exercise is one way of coping. Other methods of stress management include yoga,tai chi, meditation, massage and breathing techniques.

Nutritional Supplements:

There are a variety of supplements that can be used effectively to prevent and minimize PMS symptoms. Here are some of my suggestions:

¡P Multi-vitamin and Mineral Complex ¡V to correct any nutritional deficiencies and optimize health.

¡P B complex ¡V the B vitamins are very important for health of the nervous system and for managing stress.Vitamin B6 is particularly important for PMS, since it has natural diuretic properties; it is required by the liver to break down estrogen; and it is required for the production of serotonin and dopamine. A deficiency of this vitamin is known to worsen PMS symptoms. Look for a product containing 50 mg of each B vitamin, and take extra B6 (50-100 mg) during PMS time.

¡P Calcium has been shown to reduce many PMS symptoms,such as water retention, mood swings, cravings, and pain. Dosage range is 1000 to 1500 mg daily in divided doses.

¡P Magnesium is helpful in alleviating fluid retention and cramping. Try 300 to 500 mg magnesium citrate with your evening meal. If diarrhea occurs, reduce the dosage.

¡P Vitamin E may help reduce breast tenderness and swelling. Try 400 to 800 IU daily.

¡P Essential Fatty Acids, such as evening primrose oil and flaxseed oil may help reduce pain and inflammation, as well as some of the emotional symptoms of PMS. Try 1000 mg evening primrose oil three times daily and 1000 mg flaxseed oil twice daily.

Herbal Therapies 

¡P Phytoestrogens - plant-based compounds that are structurally similar to the estrogen that our body produces. These products work to block the effects of estrogen-dominance. Examples include soy, black cohosh and red clover. Follow package directions or the advice of your health care practitioner.

¡P St. Johns Wort - an effective treatment for mild to moderate depression. In a recent study, St. John¡¦s Wort was found to be effective in reducing nervous tension, insomnia and depression in women with PMS.(Source: British Journal of Obstetrics and Gynaecology, July 2000) Be careful about mixing St.John¡¦s Wort with prescription medication. It may interact with antidepressants, oral contraceptives and drugs taken for organ transplant.

¡P Chasteberry (Vitex) is useful for balancing hormone levels and reducing many PMS symptoms. A recent German study of 170 women found that chasteberry was effective in reducing irritability, headache, mood swings and breast  tenderness. Over half of women given chasteberry experienced a 50% or greater reduction in symptoms, with no significant adverse effects. The dosage used was 20mg daily. (Source:British Medical Journal 2001;322:134-137).

¡P Natural progesterone therapy may helpful for women with moderate to severe PMS. It helps to balance high estrogen levels, promotes relaxation and may be effective in treating PMS headaches. In Canada, this is available by prescription only.

Note:If you decide to try nutritional supplements or herbs to manage your PMS symptoms, understand that these products do not provide instant relief. Most need to be taken on a regular basis and it may take two to three months to notice the benefits. If you are taking prescription medication or have other medical conditions, check with your health care provider before supplementing.

Why do I crave sweets during that time of the month?There are a couple of theories that explain sweet cravings during PMS. The first is that cravings result from a lack of serotonin in the brain during PMS. Serotonin is a chemical in our brain that acts to elevate our mood and feeling of well being. Sweets or carbohydrates, such as chocolate and other sugar-rich foods, are converted in our body to tryptophan ¡V a precursor for serotonin. Another possibility is that excess insulin is released in response to sugar consumption. This results in low blood sugar levels and further cravings for sweets. Lastly, magnesium deficiency has been associated with carbohydrate cravings,and our magnesium levels are lower during PMS. This may explain those strong urges for chocolate. Chocolate provides us with magnesium, as well as sugar and caffeine.

Although these substances can worsen PMS symptoms, they temporarily elevate the mood and make us feel better.

Author:Sherry Torkos is a pharmacist in the Niagara area. She isthe author of ¡§Women¡¦s Health for Canadians,¡¨ by Prentice Hall Canada, 2001.

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